The group realizes their only way out is through the sewers, as the prison exit is blocked by a gigantic mutant zombie known as the "Axeman" (The Executioner). While navigating the sewers, they are attacked by zombies, splitting the group up. Bennett, the movie star, steals Alice's plane and flies to the Arcadia ship alone, leaving the others behind. Luther is pulled into a hole by zombies, presumed dead.

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Following the events of Extinction , Alice (Milla Jovovich) and her clones infiltrate the underground headquarters of the Umbrella Corporation in Tokyo. They attempt to kill Albert Wesker, the chairman of Umbrella. During the confrontation, Wesker injects Alice with a serum that neutralizes the T-virus in her body, stripping her of her superhuman powers and rendering her human again. She barely escapes the facility as it self-destructs.