6 Sim

| Challenge | Mitigation | |-----------|-------------| | Simulation bias (model ≠ reality) | Continuous calibration with real process data; Bayesian updating | | Computational cost | Use surrogate models (neural nets trained on simulation outputs) for real-time inference | | Over-reliance on prediction | Retain statistical process control as a safety monitor | | Cultural resistance | Train Six Sigma Black Belts in simulation fundamentals |

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