For organizations or individuals with specific needs, Microsoft and third-party vendors offer solutions like Microsoft Application Virtualization (App-V) that can virtualize applications, making them accessible in a more portable manner. However, these solutions are typically targeted at enterprise environments.
If you need to install Microsoft 365 on computers that have limited or no internet access, you can create a "portable installer" on a flash drive. microsoft office 365 download center portable
1. The Official "Portable" Solution: Microsoft 365 for the Web microsoft office 365 download center portable